山东省菏泽地区隔膜型布-加综合征外环境饮用水多元素测定

Effects of multiple elements in drinking water on inferior vena cava membranous obstruction type of the Budd-Chiari syndrome in Heze area of Shandong Province

目的探讨外环境因素在隔膜型布-加综合征(Budd鄄Chiarisyndrome,B鄄CS)发病中的作用。方法在已掌握的山东省菏泽市700余份B鄄CS病历的临床资料中选择128例隔膜型患者调查其生活环境,同时对外环境饮用水多元素进行检测和分析。结果128例患者饮用水金属元素均在正常值范围内;水碘测定,有98.44%的患者饮用水含碘在150μg/L以上,属于高碘地区,其中150￣300μg/L的占27.35%,300μg/L以上的占71.09%;水氟测定,饮用水含氟在正常范围的占1.56%,在轻病区范围(1.0￣2.0mg/L)的占75.00%,在中等病区范围(2.0￣4.0mg/L)的占23.44%。结论B鄄CS的发生可能与外环境饮用水高碘和高氟密切相关,碘和氟在B鄄CS的发病机制中的作用是值得进行深入研究的课题。

Objective To study the effects of environmental factors on inferior vena cava membranous obstruction type of the Budd-Chiari syndrome. Methods 128 cases of inferior vena cava membranous obstruction type were selected among 700 cases Budd-Chiari syndrome to investigate their living environment. Meanwhile, the elements of drinking water were assessed and analyzed. Results The metallic elements were within normal range in the drinking water of 128 cases. As for content of iodine in the drinking water, 98.44% of 128 cases exceeded 150 μg/L distributing in high iodine regions; 27.35% were within 150 ~ 300 μg/L; 71.09% cases were above 300 μg/L. As for content of fluorine in the drinking water of 128 cases, 1.56% cases were normal, 75.00% cases within 1.0 ~ 2.0 mg/L in mild disease region; 23.44% cases within 2.0 ~ 4.0 mg/L in moderate disease region. Conclusions Inferior vena cava membranous obstruction type of the Budd-Chiari syndrome pathogenesis is maybe related to high content of iodine and fluorine in drinking water. Iodine and fluoride are potential toxic factors in the pathogenesis of Budd-Chiari syndrome.