摘要
采用侧脑室注射胃泌素的方法，以小鼠跑完迷宫所需的时间为指标，观察了胃泌素对小鼠记忆活动的影响。侧脑室注射２ｕｌ含０．２、０．４和０．８ｕｇ胃泌素１ｈ后，小鼠跑迷宫时间及出现的错误次数均高于对照组，且随着胃泌素浓度的增加，小鼠跑迷宫时间相应延长。肌肉注射０．２５ｍｌ含０．４ｕｇ胃泌素１ｈ后，小鼠跑迷宫时间及出现的错误次数与给药前相比没有显著差别。结果提示胃泌素可引起小鼠遗忘，其作用具有中枢特异性。
The effect of gastrin on memory was observed in mice by measuring the time taken for completing a maze running.Fourty trained mice were selected and divided into 4 groups.Three groups were given 2 ul of gastrin solution 1cv(0.2,0.4and0.8μg)and one group was taken as control by injecting 2 ul of saline icv.One hour later,their memory in maze running was examined.The gastrin-treated mice took more time to reach the destination and made more errors on the way than the control.Experiment was also made by injecting gastrin im (0.4μg in 0.25ml of saline), but no effect on memory was observed.These results show that gastrin impairs memory retention in mice by acting on the CNS directly.
出处
《徐州医学院学报》
CAS
1994年第1期29-31,共3页
Acta Academiae Medicinae Xuzhou
关键词
胃泌素
侧脑室
迷宫
记忆
gastrin
cerebroventricle
maze
memory
mice
