原发性肝癌肝移植围手术期辅助治疗

Perioperative Assistant Therapy of Liver Transplantation for Primary Hepatocellular Carcinoma

目的 探讨原发性肝癌肝移植围手术期治疗的现状及研究进展。方法 采用文献回顾的方法对原发性肝癌肝移植围手术期治疗的现状及研究进展进行综述。结果 原发性肝癌肝移植围手术期治疗的方法包括:肝动脉栓塞化疗、全身化疗、放疗、瘤内无水乙醇注射以及射频毁损等。结论 原发性肝癌肝移植围手术期辅助治疗不仅为肝移植患者赢得了手术时间,而且明显提高术后生存率。

Objective To analyse the current situation and advance in perioperative therapy of liver transplantation for primary hepatocellular carcinoma(HCC).Methods The published papers on current situation and advance in the perioperative therapy of liver transplantation for HCC were reviewed.Results The survival rate of liver transplantation for HCC in early stage has been the same as that for benign liver diseases up to now. However, it is still a difficult problem to improve the survival rate of liver transplantation for advanced HCC. The ideal perioperative therapies of liver transplantation for HCC should be helpful to suppress the growth of tumor while the HCC patients are waiting for donated livers, to diminish or eliminate the intraoperative spread or implantation of tumor cells and to repress the micrometastasis postoperatively. The current perioperative therapies of liver transplantation for HCC include hepatic arterial chemoembolization, systemic chemotherapy, radiotherapy, percutaneous ethanol injection into HCC and radiofrequency ablation etc. Conclusion The perioperative assistant therapy of HCC can not only save time for patients before liver transplantation but also improve the survival rate after operation.