采用脐血对新生儿进行地中海贫血诊断的临床研究

Clinical study on diagnosis of the thalassemia to neonate by using umbilical blood.

目的 应用脐血对新生儿进行地中海贫血的筛查。方法 采用红细胞休克一管定量法及醋酸纤维素膜电泳 ,进行血红蛋白定量、定性分析。结果 在 1 4 38例脐血中 ,α -地贫的的遗传度是 1 2 .1 % ,β -地贫的的遗传度是 2 4 .1 % ,母亲遗传占 6 .81 % ,1家 3口均为地贫占 1 .6 % ,Bart′s水肿胎占 0 .6 3%。结论 应用脐血筛查地贫 ,方便、快捷 ,能有效检出α -地贫患儿 ,结果准确、可靠 ,可在临床推广应用。

Objective: To using umbilical blood detect the thalassemia to neonate.Methods: Using simple tube red cell shock quantitative test and acetic acid cellulose membrane electrophoresis quantitative analysis to hemoglobin . Results: The heritability of α- thalassemia is 12.1%, β- thalassemia is 24.1%, mather heredity is 6.81%, all families attack thalassemia is 1.6%, Bart′s edema syndrome is 0.63%. Conclusion: Using umbilical blood detect the thalassemia to neonate can detect effectively α- thalassemia infant , results is convenient and quick and accurate and dependable.