胰腺癌肉瘤临床病理分析

Clinicopathologic analysis of pancreatic carcisacoma.

目的探讨胰腺癌肉瘤的临床病理学特征。方法回顾性分析我院2例胰腺癌肉瘤的临床病理资料并结合相关文献进行讨论。结果2例胰腺癌肉瘤分别位于胰头和胰体尾,行胰头十二指肠切除术和胰体尾、脾切除术。镜下见肿瘤由癌和肉瘤两种成分混杂组成,二者无明显分界,无明显移行区。免疫组化证实癌性成分中上皮标记物EMA、Keratin阳性表达,肉瘤成分中间叶标记物Vimentin、CD68阳性表达。结论胰腺癌肉瘤是一种由癌和肉瘤组成的混合性肿瘤,恶性程度高,预后差,手术治疗是惟一延长生存时间和提高生活质量的方法。

Objective To investigate clinicopathologic features of pancreatic carcinosarcoma. Methods A retrospective clinical analysis was made of two cases of pancreatic carcinosarcoma, with a review of the relevant literature. Results Pancreatic carcinosarcoma was found in one man and one woman, with the tumor located in the head and body, respectively. They were surgically resected by pancreaticoduodenectomy and distal pancreatectomy. Histologically, the tumor consisted of two different components: carcinomatous cells and sarcomatous tumor cells. Immunohistochemical study showed positive staining of cytokeratin and epithelial membrane antigen for ductal adenocarcinoma, and negative staining for sarcomatous cells. Vimentin and CD68 stain was positive in the sarcomatous tumor and negative in the adenocarcinoma. Conclusions Pancreatic carcinosarcoma is characterized by an admixture of a carcinomatous component and a sarcomatous component, and demonstrates aggressive biological behavior. The prognosis of this admixed tumor appears to be dismal.