淋巴结外Rosai-Dorfman病

Extranodal Rosai-Dorfman disease

目的探讨淋巴结外Rosai-Dorfman病的病理学特征、诊断及鉴别诊断。方法对2例结外Rosai-Dorfman病行HE和免疫组织化学(EnVisionTM)染色观察。结果光镜下见病灶内深浅不一结节状区域,浅染区体积较大的组织细胞,呈多边形或椭圆形,其直径为淋巴细胞的10～30倍左右,胞质丰富,淡嗜酸性,核膜光滑,有小的嗜碱性核仁,部分组织细胞之胞质内见较多淋巴细胞、浆细胞等,组织细胞表达S100蛋白。结论结外Rosai- Dorfman是一种少见的组织细胞增生性病变,有一定的病理学特征。应与幼年性黄色肉芽肿、纤维组织细胞瘤、Langerhans组织细胞增生症、网状组织细胞瘤以及慢性炎症性病变等鉴别。

Objective To investigate the diagnosis and differential diagnosis of extranodal Rosai-Dorfman disease. Methods Two cases of extranodal Rosai-Dorfman disease were studied using hematoxylin-eosin, and immunohistochemical staining, along with a literature review. Results The lesions of RDD were characterized by the presence of large histiocytes with emperipolesis, accompanied by infiltration of lymphocytes, plasma cells and other inflammatory cells. The large histiocytes had an abundant cytoplasm, pale to eosinophilic in appearance, positive for S-100 protein staining, ,with a vesicular nucleus and a small basophilic nucleolus in each cell. Conclusions Extranodal Rosai-Dorfman disease is known as an idiopathic proliferative disease of histiocytes with a distinct morphologic feature and is very rare. Differential diagnosis from other types of fibrohistiocytic proliferation lesions is recommended.