摘要
用离体兔胸主动脉条研究东莨菪碱（ｓｃｏｐｏｌａｍｉｎｅ，Ｓｃｏｐ）扩张血管作用的可能机理。Ｓｃｏｐ与维拉帕米对ＣａＣｌ２和Ｓｃｏｐ对ＫＣＩ所致兔胸主动脉条收缩的量－效曲线右移，最大反应降低，呈现非竞争性拮抗，其ｐＤ＇２分别为３．４，５．８和３．４。两药能明显抑制ＮＥ的依赖内Ｃａ（２＋）性收缩，Ｓｃｏｐ对ＮＥ的依赖外Ｃａ（２＋）性收缩几无影响，表明Ｓｃｏｐ可能主要作用于电压依赖性的钙通道，阻断Ｃａ（２＋）内流。
Scopolamine(Scop)or verapamil(Ver)inhibited the contraction of isolated rabbit thoracic aortia(TA) induced by CaCl2 and KCl.Scop,like Ver,shifted the dose-response curves of CaCl2 and KCl to the right, and depressed their maximal responses, with the pD'2 values being 3.4 in both eases Scop, like Ver, inhibited the intracellular Ca(2+)-dependent component of NE-induced contraction of aorta, but did not decrease the extracellular Ca(2+)-dependent component. These results suggest that Scop,similar to Ver,mainly acts on the potential-operated calcium channel and blocks the influx of Ca(2+).
出处
《徐州医学院学报》
CAS
1994年第2期117-119,共3页
Acta Academiae Medicinae Xuzhou
关键词
东莨菪碱
主动脉
血管平滑肌
钙
scopolamine
verapamil
thoracic aorta
doseresponse relationship
vascular smooth muscle
