鼠原发性三叉神经痛下丘脑β内啡肽含量测定

Determination of β-endorphin in hypothalamus of rat with primary trigeminal neuralgia

目的 检测鼠三叉神经痛脑组织中β内啡肽含量及其生理作用。方法 取Wister大鼠 37只,分为实验组 20只,生理盐水组 10只,空白对照组 7只。建立鼠三叉神经痛实验动物模型,采用放射免疫测定β内啡肽含量。结果 实验组明显低于生理盐水组和空白对照组,P<0 01。结论 脑组织中β内啡肽含量明显降低是引起鼠原发性三叉神经痛的重要原因之一。

Objective To determine the level and the role of β endorphin in hypothalamus of rat with trigeminal neuralgia.Methods The animanl model of primary trigeminal neuralgia in rat was established,the contents of β endorphin were measured by radioimmunoassy techniques.Results The β endorphin of hypothalamus in experimental group was significantly lower than other groups ( P <0 01).Conclusions β endorphin may play important roles in primary trigeminal neuralgia.