311例SARS患者康复后一年内血清IgG抗体变化分析

Study on the dynamics of IgG antibody in 311 patients with severe acute respiratory syndrome

目的 了解严重急性呼吸综合征(SARS)患者康复后一年内血清中 SARS冠状病毒(SARS-CoV)特异性抗体 IgG的产生水平及动态变化。方法 SARS患者康复后,每隔2-4周抽取IgG抗体阳性的SARS康复期患者血液,经病毒灭活后分离血清,用酶联免疫吸附试验检测 SARS-CoV特异性抗体 IgG;利用Stata 7.0统计学软件对各月份的检测结果进行分析。结果 各康复期患者的各次检测结果均为阳性,出院后约 35 天时抗体平均水平最高。一年内, IgG抗体平均水平呈逐渐下降趋势,下降幅度约为35.8%。结论 SARS康复期患者康复后短期内具有较高水平的 IgG抗体,但随着康复时间的推移,该抗体呈逐渐下降趋势。提示应对该抗体进行长期监测,直至该抗体消失。

Objective To detect the level and dynamic change of severe acute respiratory syndrome(SARS)-coronavirus-specific IgG antibody in conavalescent SARS patients, and to provide information for prevention and vaccine development. Methods IgG antibody against coronavirus was detected by ELISA in the blood of 311 convalescent SARS patients for every 2-4 weeks. Stata (7.0) statistics software was used to analyse the results. Results IgG antibody was detected positive on each testing of all the convalescent patients and its peak appeared 35 days after recovery. IgG antibody level showed a 35.8% decrease within one year. Conclusion Data showed that all the SARS convalescent patients had generated high level of specific IgG antibody against coronavirus in the early stage of recovery, but the antibody level declined along with the progress of convalescence, suggesting that the detection of the IgG antibody should go on until it disappeared.