摘要
以野百合碱引起的大鼠肺动脉高压作为模型，应用免疫组化和形态定量的方法，并结合超微结构的变化，动态观察肺动脉高压时腺泡内肺动脉壁Ⅰ、Ⅲ型胶原含量的改变。结果表明，在肺动脉高压发生过程中，腺泡内肺动脉壁Ⅰ、Ⅲ型胶原明显增多。其机制可能与血管平滑肌细胞发生表型变化以及平滑肌前体细胞在向平滑肌转变过程中胶原的合成分泌增多有关。
Pulmonary hypertension (PHT)in rats was induced with monocrotaline (MCT).Immunohistochemistry and morphometry,combined with electron microscopy,were applied to investigate the quantitative changes of collagen Ⅰ and Ⅲ in the intraacinar pulmonary artery (IAPA),The results indicated that collagen Ⅰand Ⅲ increaced obviously during the development of PHT. The increases of collegen may be related to the phenothypic changes of vascular smooth muscle cells (SMC) and to the proliferation and muscularoid differentiation of pericytes (PC) in IAPA.
出处
《徐州医学院学报》
CAS
1994年第4期283-285,共3页
Acta Academiae Medicinae Xuzhou
基金
国家"八五"攻关课题资助
关键词
胶原
免疫组织化学
形态定量
肺动脉高压
pulmonary hypertension
collagen
pericyte
immunohistochemistry
morphometry
rat
