加替沙星治疗急性下呼吸道感染的疗效评价

Evaluation on the effect of Gatifloxacin therapy in lower respiratory tract acuteinfections

目的评价加替沙星治疗急性下呼吸道感染的疗效和安全性.方法 35例患者接受加替沙星200mg静脉滴注治疗,每日两次;36例患者接受左氧氟沙星200mg静脉滴注治疗,每日两次;32例患者接受环丙沙星200 mg静脉滴注治疗,每日两次,疗程均为7～14天.结果加替沙星组、左氧氟沙星组痊愈率和有效率分别为77.14%、72.22%与91.43%、77.78%(P＞0.05),加替沙星组和环丙沙星组痊愈率和有效率分别为77.14%、53.13%与91.43%、65.63%(P＜0.05).加替沙星组和左氧氟沙星组细菌清除率分别为87.88%、85.29%(P＞0.05),加替沙星组和环丙沙星组细菌清除率分别为87.88%、65.62%(P＜0.05).结论国产加替沙星抗菌谱广,抗菌活性强,副作用小,且疗效明显优于环丙沙星,能安全有效地治疗急性下呼吸道感染,有较高的临床应用价值.

Objective To evaluate the clinical efficacy and safety in a randomized controlled clinical study on Gatifloxacin and Levofloxacin,Cipofloxacin treatment of lower respiratory tract acute infections.Methods Thirty-five patients were treated with 200mg of Gatifloxacin twice daily intravenously;36 patients were treated with 200mg of Levofloxacin twice daily intravenously;32 patients in the Cipofloxacin group were treated with 200mg of Cipofloxacin twice daily intravenously.The courses of treatment were 7～14 days in all groups.Results The cure and effective rates of the Gatifloxacin and Levofloxacin groups were 77.14%、 72.22% and 91.43%、 77.78%(P> 0.05),respectively.The cure and effective rates of the Gatifloxacin and Cipofloxacin groups were 77.14%、 53.13% and 91.43%、 65.63%(P< 0.05) ,respectively.Bacterial eradication rates of the Gatifloxacin and Levofloxacin groups were 87.88% and 85.29%(P> 0.05).Bacterial eradication rates of the Gatifloxacin and Cipofloxacin groups were 87.88% and 65.62%(P< 0.05).Conclusions The results suggest that the domestic Gatifloxacin has characteristics with broad spectrum,powerful antibacterial activity and light adverse drugs reaction.Furthermore its efficacy is higher than Cipofloxacin.It can be used to treat lower respiratory tract acute infections safely and effectively.It has comparatively high value of clinical application.