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过氧化物酶体增殖物激活受体的医学重要性 被引量:3

Significance of Peroxisome Proliferators-Activated Receptors in Medicine
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摘要 过氧化物酶体增殖物激活受体(peroxisome prolifera(?)o(?)s activated receplors,PPARs)是Ⅱ型受体超家族成员,有PPAR(α)、PPAR(β)、PPAR(γ)3个亚型,它们参与脂类代谢、线粒体代谢、细胞分化、细胞周期和细胞凋亡的调节,对研究肥胖和糖尿病及肿瘤的发病机制有十分重要的意义。 The peroxisome proliferators-activated recep(?)ors (PPARs) are nuclear hormone receptors which contain PPAR(α), PPAR(β) and PPAR(γ). They are modulators of lipid metabolism, mitochondrion metabolism, cell differentiation, cell cycle and apoptosis. Therefor, they are of great importance in the researches of the pathogenesis of obesity, diabetes and tumor etc.
出处 《医学分子生物学杂志》 CAS CSCD 2005年第2期140-142,共3页 Journal of Medical Molecular Biology
基金 国家自然科学基金(No.39880044)~~
关键词 过氧化物酶体增殖物受体 脂类代谢 肿瘤 peroxisome proliferators-activated receptors (PPARs) lipid metabolism tumor
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参考文献12

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同被引文献11

  • 1高福生,李淑兰.慢性阻塞性肺疾病患者的骨骼肌功能障碍[J].国外医学(呼吸系统分册),2005,25(3):192-193. 被引量:2
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  • 3RAJPUT M S,BALEKAR N,JAIN D K.Lagenaria siceraria ameliorates atheromatous lesions by modulating HMG-Co A reductase and lipoprotein lipase enzymes activity in hypercholesterolemic rats[J].Journal of Acute Disease,2014,3:14-21.
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  • 6MARTIN G,DUEZ H,BLANQUART C,et al.Statin-induced inhibition of the Rho-signaling pathway activates PPARa and induces HDL apo A-I[J].Clin Invest,2001,107:1423-1432.
  • 7GUAN Y.PPAR family and its relationship to renal complications of the metabolic syndrome[J].J Am Soc Nephrol,2004,15:2801-2815.
  • 8BARBIER O,DURAN-SANDOVAL D,PINEDA-TORRA I,et al.Peroxisome proliferator-activated receptor alphainduces hepatic expression of the human bile acid glucuronidating UD P-glucuronosyltransferase 2B4 enzyme[J].J Biol Chem,2003,278(35):32852-32860.
  • 9李建新,孙于庆,岳福兴,张晓宇,艾志录.苹果多酚对小鼠体重控制作用的研究[J].现代食品科技,2013,29(3):490-493. 被引量:4
  • 10姚艳,王宗保,唐朝克.PPARs在长链脂肪酸调控能量代谢中的作用[J].生理科学进展,2016,47(1):1-6. 被引量:7

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