三七皂苷对急性冠脉综合征冠脉支架植入术后P-选择素、组织型纤溶酶原激活物及其抑制物的影响

Effects of Panax Notoginseng Saponins on P-selectin, tissue-type plasmiogen activitor and plasminoge activitor inhibitor-1 levels in patients with acute coronary syndrome after intracoronary stent implantation

目的 :观察三七皂苷对急性冠脉综合征冠脉支架植入术后患者血中 P-选择素、组织型纤溶酶原激活物及其抑制物的影响。方法 :4 4例急性冠脉综合征行冠脉支架植入术成功的患者 ,随机分为西药常规治疗 (对照组 ,2 2例 )和西药常规加路路通 (三七皂苷 )治疗 (加中药组 ,2 2例 )。对患者术前及术后 1d、术后 1个月分别采肘静脉血 6 m L ,用双抗体酶联免疫吸附试验 (ABC- EL ISA)测血清中 P-选择素 (Ps)、组织型纤溶酶原激活物 (t- PA )及其抑制物 (PAI- 1)浓度水平。结果 :与冠脉植入术后 1d比较 ,加中药治疗 1个月后血清中 Ps的浓度 (9.170±1.5 0 0 ) g· L- 1 及 PAI- 1的活性 (0 .5 84± 0 .0 75 ) k AU· L- 1 均显著降低 (P<0 .0 5 ) ,而血浆中 t- PA的活性 (0 .877±0 .132 )明显升高 (P<0 .0 5 )。结论 :三七皂苷影响纤溶系统 ,从而减少急性冠脉综合征冠脉支架植入术后冠脉内局部血栓形成 ,防止支架术后再狭窄。

Objective To evaluate the effects of Panax Notoginseng Saponins on P-selectin (Ps), tissue-type plasmiogen activitor (t-PA) and plasminoge activitor ihibitor-1 (PAI-1) levels in patients with acute coronary syndrome after intracoronary stent implantation.Methods Forty four patients with successful intracoronary stent implantation were divided into routine treatment group (control group,n=22),routine combined with Lu-Lu-Tong (including Panax Notoginseng Saponins 25 g·L~ -1) treatment group (treatment gorup,n=22) at random. For each case, 6 mL elbow venous blood were collected 24 h before implantation, 1 d and 1 month after implantation, and then the serum Ps, t-PA, and PAI-1 levels were detected by ABC-ELISA.Results The levels of Ps (9.170±1.500)g·L~ -1 and PAI-1(0.584±0.075)kAU·L~ -1 1 month after implantation were both significantly decreased (P<0.05), compared with 1 d after implantation. While the level of plasma t-PA (0.877±0.132)was significantly increased compared with control group. Conclusion Panax Notoginseng Saponins are beneficial to the patients after intracoronary stent implantation through regulating the t-PA/PAI system.