益脑通络胶囊预防微血管内血栓形成实验研究

The study of Yinaotongluo capsule preventing the microcirculation dysfunction in rats

目的 研究益脑通络胶囊对大鼠微循环障碍的改善作用。方法 40 只大鼠随机分为模型组、益脑通络胶囊小、中、大剂量预防组和步长脑心通胶囊对照组,每组8只;利用光化学原理,从静脉内注射光敏剂,经光照射后产生光化学作用引起血管内皮损伤、细胞黏附和血栓形成,通过微循环显微摄像技术,观察、记录、分析微循环的变化。结果 光照后,益脑通络胶囊小、中、大剂量预防组血栓形成时间均明显长于模型组( P <0.01),而且较模型组能有效缩小血管堵塞面积( P <0.01),其中中剂量组缩小血管堵塞面积的效果优于步长脑心通组( P <0.05)。结论 益脑通络胶囊具有改善肠系膜微循环的作用,在某种程度上对全身的微循环损伤也有预防作用。

ObjectiveTo explore the effect of Yinaotongluo capsule on preventing the microcirculation dysfunction in rats.Methods40 SD rats were randomly divided into the thrombosis model group, three Yinaotongluo capsule groups (low, moderate and high dosages) and control group with 8 rats in each group. Photosensitizer was injected through vessel. Endothelium damage, cell adhesion and thrombosis were induced by photochemistry. The change of microcirculation was recorded and analyzed by microphotography technique.ResultsYinaotongluo capsule groups could prolong the time to thrombosis induced by photochemistry compared with control group ( P<0.05). However, the area of thrombus to vessel significantly decreased in all Yinaotongluo capsule groups compared with control group ( P<0.01). The effect of moderate dosage group of Yinaotongluo capsule was superior to Buchangnaoxintong group.ConclusionYinaotongluo capsule can improve the microcirculation of mesentery of rats, in part it can improve the systematic microcirculation of rats. [