帕罗西汀对多发性硬化伴抑郁状态及神经功能康复的影响

Effect of paroxetine on multiple sclerosis with depression and neurological functional rehabilitation

目的 观察帕罗西汀治疗多发性硬化抑郁状态的疗效及对神经功能康复的影响。方法 将60例多发性硬化伴抑郁患者按病情相匹配的原则分为治疗组31例,对照组29例,分别用帕罗西汀、氟西汀治疗;于治疗前、治疗后4周、8周进行汉密顿抑郁量表(HAMD)、汉密顿焦虑量表(HAMA)、日常生活活动能力(ADL)量表测定,治疗前、治疗后8 周进行听觉 P300 测试。结果 两组治疗前后HAMD、HAMA和ADL测定,以及听觉P300测试,组间比较无显著性差异( P >0.05),组内比较有非常显著性差异( P <0.01)。结论 帕罗西汀能有效治疗多发性硬化抑郁状态,促进神经功能康复。

ObjectiveTo observe the effect of paroxetine on multiple sclerosis with depression and neurological functional rehabilitation.Methods60 patients with multiple sclerosis and depression were randomly assigned to two groups that were treated with paroxetine and fluoxtine. The effect was evaluated with Hamilton depression scale (HAMD), Hamilton anxiety scale (HAMA), activities of daily living scale (ADL) and P300 test.ResultsThere were not differences in scores of HAMD, HAMA, ADL and P300 before and aftet the treatment in both paroxetine and fluoxtine groups ( P>0.05), but there were significant differences in same group before and aftet the treatment ( P<0.01).ConclusionParoxetine is effect on multiple sclerosis with depression effectively and able to accelerate neurological functional rehabilitation. [