灌流式生物反应器内支架材料孔隙流场和壁面剪应力的数值分析

Numerical Analysis for the Lacune Fluid Field And Wall Shear Stress of Scaffold in the Perfusion Bioreactor

为获得支架材料孔隙受到的壁面剪应力的大小及分布、孔隙内压力分布以及支架材料与灌流小室之间不同缝隙时的灌流率。根据有限元方法建立了灌流式生物反应器小室内 3种支架材料孔隙模型 ,用an sys软件分析了各种模型在不同工况下的灌流情况。结果表明 ,支架材料与灌流小室之间的孔隙决定灌流率 ,缝隙大于 0 .5mm时灌流率小于 6 0 % ;支架材料孔隙壁面剪应力大小主要受灌流流量的影响 ,调节灌流流量是控制剪应力水平的主要手段。孔壁剪应力和孔内流体压力的分布均由支架材料孔隙的形状特征所决定。

To attain values and distributions of hole′s wall shear stress and hydropress in scaffolds separately, the rates of perfusion in different lacunes between the scaffold and the perfusional unit are calculated. Different hole′s models about three kinds of scaffolds by the finite elements method were set up, then perfusion features of these models were analyzed by the software ANSYS. Results showed that the perfusion rate was decided by the lacune between the scaffold and the perfusional unit, in this paper′s model, the rate was less than 60% when the lacune was much than 0.5mm; the wall shear stress was mainly affected by the perfusion flux, so tuning up the perfusion flux was the mostly method of adjusting the wall shear stress value. The distribution of the wall shear stress and the hydropress in the scaffold are mainly determined by figure characters of the scaffold.