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后期促进因子与细胞周期 被引量：1

Anaphase-Promoting Complex and Cell Cycle
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摘要 近年来,发现了细胞周期中许多关键的调控因子,cdc 基因、周期蛋白依赖性激酶(CDKs)及细胞周期蛋白(cyclin)等。其中有丝分裂后期促进因子(APC)构成泛素 蛋白水解酶复合体通路,参与周期蛋白和周期蛋白依赖激酶降解,促进细胞周期的运转。同时,APC的活性也受到 G1 期和 M期的细胞周期依赖蛋白激酶(CDK)的调节, cdc20 为APC的正调控因子,APC与细胞周期各因子间协调作用,促进细胞周期的运转。 Many regulation-factors related to cell cycle such as cell division cycle genes (cdc) and cyclin-dependent kinases(CDKs) have been determined.Here we review the progress in research on APC-anaphase-promoting complex.APC is a component of Ubiquitin-proteasome pathway.APC degrades Cyclin and CDKs and leads directly to cyclical changes.G1-CDKs and M-CDKs triggers the activity of APC.The activation of APC requires the protein cdc20.APC with many cell-cycle factor in turn triggers cell cycle changes.
作者 石娇 于维军 于业辉
机构地区 沈阳农业大学畜牧兽医学院
出处 《动物医学进展》 CSCD 2005年第3期23-25,共3页 Progress In Veterinary Medicine
基金 沈阳农业大学青年科研基金资助项目
关键词 后期促进因子 细胞周期 泛素-蛋白 水解酶复合体通路 anaphase-promoting complex cell-cycle ubiquitin-proteasome pathway
分类号 Q71 [生物学—分子生物学]
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参考文献16

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动物医学进展
2005年 第3期

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