高脂血症与良性前列腺增生相关性的临床研究

Correlation of benign prostatic hyperplasia with hyperl ipemia

目的 探讨高脂血症对良性前列腺增生 (BPH)临床进展的影响及BPH的发病机理。方法 对有下尿路梗阻症状经前列腺切除术后病理证实的 462例BPH进行回顾性分析研究。结果462例中,BPH合并高脂血症 232例(50 .22 % )。与单纯BPH相比,BPH合并高脂血症患者的前列腺体积明显增大(P=0 .029),残余尿量明显增多 (P=0 .03)。BPH合并高脂血症患者不同血脂成分对BPH临床参数影响的研究显示高密度脂蛋白的降低与前列腺体积的增大以及血清前列腺特异性抗原的升高密切相关 (P<0 05;P<0. 05 );BPH合并高脂血症患者中有 39. 2%同时伴发高血压。BPH患者中高脂血症伴发高血压导致IPSS(国际前列腺症状学评分 )明显增加 (P=0 .004 )。结论BPH合并高脂血症临床多见,高密度脂蛋白的降低与前列腺体积增大密切相关。高脂血症同时伴发高血压明显加重BPH的下尿路症状。高脂血症有可能是BPH发生与临床进展的危险因素。

Objective To investigate re la tionship between benign prostatic hyperplasia (BPH) and hyperlipemia, and to cle ar out possible factors related to BPH etiology. Methods A total of 462 cases of BPH diagnosed by pathological examination wer e studied retrospectively. Results Of 462 cases, BPH with hyperlipemia was noted in 232 cases (50.22%) . In comparison with the data of simple BPH, both prostate volume (P=0.029 ) and residual urine (P=0.03) were significantly increased in the BPH patie nts with hyperlipemia. Statistical analysis regarding the effects of different components of serum lipid on BPH clinical factors showed that the level of high density lipoprotein was significantly associated with both the enlargement of pr ostate volume (P< 0.05) and increasing of serum PSA (P<0.05) Further s tudy indicated that hypertension was demonstrated in 39.2% patients of BPH with hyperlipemia. Hyperlipemia accompanied with hypertension in BPH patients was s ignificantly related to increased IPSS (P=0.004). Conclusion The situation of BPH with hyperlipemia is frequently noted in clinics , and the decreased level of high-density lipoprotein is significantly associat ed with the enlargement of prostate volume. Co-existence of hypertension with hyperlipemia in BPH patients greatly worsens the lower urinary tract symptoms (L UTS) of BPH. Hyperlipemia may be one of the risk factors in the processes of BP H growth and progression.