超短波治疗对COPD患者诱导痰中炎症细胞及IL-8和TNF-α的影响

Clinical study of change of cytokines in induced sputum of patients with chronic obstructive pulmonary disease treated with ultrashortwave diathermy

目的研究超短波对慢性阻塞性肺疾病(COPD)患者气道炎症细胞及细胞因子的影响. 方法将74例急性发作期COPD患者分为超短波治疗组(治疗组)42例和对照组32例.治疗组除常规治疗外行超短波治疗10～14 d,对照组仅行常规治疗.2组患者均在治疗前、后分别计算诱导痰液中中性粒细胞占白细胞的百分比(Neu/Leu%),检测诱导痰液中白介素8 (IL-8)、肿瘤坏死因子α(TNF-α)以及肺通气功能指标用力肺活量(FVC)和第一秒用力呼气量(FEV1.0). 结果与对照组比较,治疗组治疗后痰液Neu/Leu%、IL-8、TNF-α均显著降低(P<0.05),FVC的实测值占预计值的百分比(FVC%pred)、FEV1.0的实测值占预计值的百分比(FEV1.0%pred)明显升高(P<0.05).Neu/Leu%与IL-8呈正相关 (P<0.05),Neu/Leu%、IL-8、TNF-α含量与FEV1.0均呈负相关(P<0.05). 结论超短波治疗COPD具有减轻气道炎症、提高肺通气功能的作用.

Objective To investigate the effect of ultrashortwave diathermy on the airway inflammation in patients with chronic obstructive pulmonary disease(COPD). Methods Seventy-four cases of COPD were divided into 2 groups, a treatment group with 42 cases treated with both ultrashortwave and conventional treatment and a control group with 32 cases treated with conventional treatment. The induced sputum samples were obtained and pulmonary function parameters such as FVC and FEV_~1.0 were tested before and after 10 to 14 days of treatment, respectively. The interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α) in induced sputum were determined by immunoassay, and the neutrophil/ leucocyte ratio (Neu/Leu%) in sputum was calculated. The relationship between IL-8,TNF-α and FEV_~1.0 were analysed. Results Compared with those of the control group, the Neu/Leu%,IL-8,TNF-αin induced sputum were significantly decreased after the treatment with ultrashortwave(P<0.05). The FVC, FEV_~1.0 increased in the treatment group more significantly than those in control group(P<0.05). There was obviously positive correlation between the Neu/Leu% and IL-8 (P<0.05). FEV_~1.0 was negatively correlated to Neu/Leu% (r=-0.89,P<0.05) and IL-8(r=-0.88,P<0.05)and TNF-α(r=-0.75,P<0.05). Conclusion Ultrashortwave diathermy is beneficial for COPD patients to improve their ventilation by antiinflammation in airway.