鲎试剂方法检测木糖醇注射液中细菌内毒素

Bacterial Endotoxin Test of Xylitol Injection by Limulus Test

目的:建立快速的木糖醇注射液中细菌内毒素鲎试剂检查法,替代家兔热原检查法。方法:用不同厂家的鲎试剂对不同批号的木糖醇注射液分别进行干扰试验,考察确立木糖醇注射液细菌内毒素检查法。结果:5%木糖醇注射液不干扰鲎试剂与细菌内毒素的凝集反应,检查结果全部为阴性,结果准确可靠。结论:木糖醇注射液可以用鲎试剂检查法取代家兔热原检查法。

Objective: To study the bacterial endotoxins test of xylitol injection using limulus lysate agent . Methods: By interfering test, the inhibition/enhancement action of xylitol with limulus lysate agent was studied. Results: There was no interference between the sample and the relative tachypleus amebocyte lysate(TAL). Conclusion: The result of bacterial endotoxins test is the same as that of pyrogen test in healthy mature rabbits.