国内灼口综合征疗效的循证医学研究及Meta分析

An evidence-based medicine study and Meta-analysis on domestic literature of treatment to buring mouth syndrome

目的对目前国内有关灼口综合征治疗的临床研究进行循证医学分析,为治疗灼口综合征提供指导。方法检索2 0 0 3年7月前发表在国内中文期刊上所有相关文献,对其进行循证医学分析,并对符合要求的文献进行Meta分析。结果共检索到32篇有关BMS临床治疗的研究。无大样本随机对照研究报道,B级文献18篇、C级文献14篇,各研究均报道对灼口综合征治疗有效;其中5篇有关雌激素替代疗法文献的Meta分析表明,雌激素替代疗法治疗更年期女性灼口综合征的疗效明显优于维生素类。结论雌激素替代疗法可作为治疗更年期前后女性灼口综合征的首选方法之一;局部神经封闭、毫米波理疗、穴位注射、中西医结合疗法治疗灼口综合征治疗的确切疗效,尚有待于进一步研究证实。

Objective To conduct an evidence-based study on the effects of comprehensive treatments to burning mouth syndrome (BMS) in Chinese literture and to develop a guide for BMS therapy.Methods All medical literature published on domestic journals before July of 2003 were collected and analyzed using the standardized Evidence-Based Medcine (EBM) methods. Meta-analysis was performed for those trials that met the inclusion criteria.Results A total of 32 EBM articles on treatment of BMS were found in the database. None of them could be classified as randomly designed case-control study. There were 18 level B trails and 14 level C articles. All of them concluded positive treatment results on BMS. Meta-analysis based on 5 clinical trials indicated that estrogen was more effective than vitamine in treatment of BMS for menopausal women. Conclusion Estrogen is effective for treating menopausal women with BMS. The efficacy and validity of local nerve obturation millimeter therapy, acupoint injection, and the combination of traditional Chinese and Western medcine approaches need further investigation.