情绪及药膳调和对肝癌化疗患者生活质量的改善

Effects of emotional intervention and Chinese medicated diet in improving the quality of life in patients with liver cancer after chemotherapy

目的:目前国内外对已失去手术机会的原发性肝癌患者的首选疗法是肝动脉化疗栓塞,但其副作用是严重的消化道症状及发热,给患者的生活质量带来了极大的负影响。探讨以膳食疗法结合情绪干预观察其对疗栓塞后患者生活质量的改善作用。方法:实验于2003-01/2004-07在商丘市第一人民医院肿瘤科完成,将收治的102例中符合纳入标准的94例原发性肝癌患者随机分为研究组和对照组,对照组在化疗栓塞后执行常规治疗方案,研究组则在其基础上增加情绪干预和药膳调和疗法。结果:2个月后研究组肝生化指标犤谷转氨酶(355.1±205.0)nkat/L,谷草转氨酶(728.5±330.1)nkat/L,碱性磷酸酶(1630.3±985.2)nkat/L,乳酸脱氢酶(4229.2±2302.1)nkat/L,r-谷氨酰转肽酶(3890.8±913.5)nkat/L,血清和胆汁中总胆红素(12.9±9.1)μmol/L,直接胆红素(3.5±1.4)μmol/L犦,与对照组比较差异有显著性意义(P<0.001)。研究组疲乏、恶心呕吐、食欲不振及整体健康状况等与治疗前比较差异有显著性意义(P<0.05)。结论:情绪干预配合药膳疗法有助于肝癌化疗栓塞后肝功能的恢复,改善躯体症状,提高患者的生活质量。

AIM:At present,the firstly chosen therapy for primary liver carcinoma of patients who have lost the chance being operated is hepatic arterial chemoembolization(HACE) home and abroad,but such side effects as serious symptom of digestive tract and febrile have brought negative influence to the quality of life in patients.To investigate the effects of emotional intervention and diet therapy on the improvement of emotion and quality of life(QOL) in patients with primary liver carcinoma after HACE is the purpose of this article.METHODS:The experiment was conducted in the Department of Oncology,First People's Hospital of Shangqiu City from January 2003 to July 2004.Ninety four patients with primary liver cancer in accordance with the inclusion criteria were selected from 102 inpatients and then were randomly divided into study group and control group.All the patients received conventional treatment after HACE,besides,emotional intervention and Chinese meclicated diet were given to those in the study group.RESULTS:After 2 months,the liver biological indexes including the levels of glutamic pyruvic transaminase,glutamic oxalacetic transaminase,alkaline phosphatase,lactic dehydrogenase,r glutamyl transpeptidase,total bilirubin in serum and bile,and direct bilirubin were (355.1± 205.0),(728.5± 330.1),(1 630.3± 985.2),(4 229.2± 2 302.1),(3 890.8 ± 913.5) nkat/L,(12.9± 9.1) and (3.5± 1.4) μ mol/L in the study group respectively,significantly different from those in the control group(P< 0.001).The symptoms such as tiredness,nausea,emesis,anorexia and general healthy status were significantly improved in the study group after treatment than before treatment(P< 0.05).CONCLUSION:Emotional intervention combined with Chinese medicated diet is good for the recovery of liver function,the amelioration of somatic symptoms and the improvement of QOL in patients with liver cancer after HACE.