早期骨关节炎评估中分子标志物的意义

Significance of the molecular marker in the evaluation of the early osteoarthritis

目的:骨关节炎早期诊断困难,常在出现临床症状之前,关节结构和功能就已经出现难以恢复的巨大变化。因此,寻求早期诊断评估方法具有重要意义。资料来源:应用计算机检索PubMed1992-01/2004-04的骨关节炎的相关文章,检索词为“osteoarthritis,marker,molecularmarker,evaluation,限定语言为English。同时检索中文期刊全文数据库(CJFD)2003-01/2004-01的骨关节炎的相关文章,检索词为“骨关节炎、诊断”。资料选择:对所选资料进行初审,排除综述性文献,对实验研究中的随机、盲法、对照等条件不做限制。资料提炼:共收集到22篇有关骨关节炎评估的实验研究文献,排除7篇重复研究,2篇Meta分析研究。13个试验符合纳入标准。资料综合:13个试验中研究对象包括患者和兔等骨关节炎模型动物,对其中的13个常见分子标志物进行重点分析。结论:联合检测多个分子标志物水平可望对早期骨关节炎进行正确诊断和评估,为早期干预和预防功能障碍提供实验参考指标。

OBJECTIVE:The early stages of osteoarthritis(OA) are difficult to diagnose.The joints show difficulty in recovery of the structure and function long before OA presents as a clinical symptom.Thus,the investigation of methods for early diagnosis and evaluation of OA possesses important significance.DATA SOURCES:The related articles to OA between January 1992 and April 2004 were searched for in PubMed by using computer.The key words were “ osteoarthritis,marker,molecular marker,evaluation' and the language used in articles was limited in English.Meanwhile,the relevant articles to OA between January 2003 and January 2004 were also searched for in China Journal Full text Database(CJFD) with the key words of “ osteoarthritis, diagnosis' in Chinese.STUDY SELECTION:After the first trial for all the articles,the review articles were excluded,and the randomized,blind and controlled methods used in articles were not limited.DATA EXTRACTION:Totally 22 literatures about experimental studies were collected,of which 7 repeated studies and Meta analytic studies were excluded.Thus,13 experimental researches were in accordance with the inclusion criteria.DATA SYNTHESIS:The studying subjects in the 13 trials included patients,rabbits and other animal models with OA.Thirteen common molecular markers were analyzed emphatically in all 13 obtained literatures.CONCLUSION:Associated measurement of several molecular marker level is expected to get correct diagnosis and evaluation of early OA so as to provide experimental and referenced indicators for the early intervention and prevention of OA.