端粒酶的结构功能与前列腺癌的相关性研究进展

Correlation between structure and function of telomerase and prostate cancer

目的:端粒酶是一种特殊的DNA聚合酶,它能以自身内源性RNA为模板合成端粒序列并添加到染色体末端上,稳定染色体,阻止细胞分裂衰亡。端粒酶的激活是肿瘤获得无限生长能力的关键步骤,是众多肿瘤发展所必需的。对端粒酶的结构、功能及其对前列腺癌早期诊断、预防及为保存前列腺器官功能的早期治疗中的价值进行综述。资料来源:应用计算机检索Medline数据库1990-01/2003-12相关端粒酶的文章,检索词“telomerase,prostateneoplasm,限定文章语言种类为英文。同时计算机检索中国期刊全文数据库、万方数据库2000-01/2003-12相关端粒酶的文章,检索词“端粒酶;前列腺肿瘤”,限定文章语言种类为中文。资料选择:对资料进行初审。纳入标准:有关端粒酶的结构功能与前列腺癌相关性的文献。排除标准:文献中重复研究、综述、Meta分析类文章。资料提炼:共收集到13篇有关端粒酶结构功能的文献,10篇有关端粒酶与前列腺癌相关性的文献。查找全文。资料综合:将所选资料按照以下顺序归纳总结:①端粒酶的结构与功能。②端粒酶与肿瘤的关系。③端粒酶在前列腺癌诊断、治疗中的应用。结论:端粒酶的激活与细胞的永生化和恶性肿瘤的发生发展密切相关。

OBJECTIVE:Telomerase,a special It also stabilizes chromosome and inhibits cell division and papoptosis.DNA polymerase,can catalyze the addition of telomeric repeats onto the ends of chromosomes using the self endogenous RNA subunit as a template.It also stablizes chromosome and inhibits cell division and apoptosis.Activating telomerse is essential for unlimited cell proliferation and the development of most tumors.This article aims to investigate the structure and function of telomerase,review its role in the early diagnosis and prevention of prostate cancer,and discuss the value of telomerase expression in the early preservation of prostatic organs' function.DATA SOURCES:The relevant articles to telomerase between January 1990 and December 2003 were searched for in Medline with the key words “ telomerase,prostate neoplasm' in English by using computer.Similarly,the relevant articles to telomerase between January 2000 and December 2003 were searched for in China Journal Full text Database(CJFD) and Wangfang Database with the same key words as above in Chinese also by using computer.STUDY SELECTION:The articles were browsed firstly.The inclusion criteria were for those articles about the structure and function of telomerase,and the relationship between telomerase and prostate cancer.The exclusion criteria were for those about repetitive studies,reviews,Meta analysis.DATA EXTRACTION:Totally 13 articles about the structure and function of telomerase and 10 articles about the relationship between telomerase and prostate cancer were collected.Then,the full texts of the articles were looked through.DATA SYNTHESIS:The selected data were summarized in the following order:① The structure and function of telomerase;② The relationship between telomerase and cancer;③ The application of telomerase in the prostate cancer.CONCLUSION:Telomerase activity is closely correlated with the immortalization of cells and the occurrence and development of malignant tumors.The detection of telomerase activity and the gene therapy with telomerase as the target provide experimental values for the prevention and early intervention of prostate cancer.