骨髓干细胞移植治疗运动神经元病的近期效果:72例疗效分析

Short-term effect of transplantation of marrow stem cell on motor neuron disease:analysis of therapeutic effect in 72 patients

目的:观察自体骨髓干细胞移植治疗运动神经元病的近期疗效,探讨对其功能改善作用。方法:2004-02/10对经解放军第四六三医院神经内科临床确诊为运动神经元病的72例患者实施自体骨髓干细胞移植,围手术期给予营养神经等药物治疗。疗效评估以肌张力是否下降,言语不清、吞咽困难是否改善,抬头困难是否改善,肌束震颤次数是否减少,肌力是否增高为标准。如以上各项任何一种症状缓解即为有效。结果:5种症状均减轻者2例,任意4种症状得到缓解者6例,任意3种症状得到缓解者20例,任意2种症状得到缓解者28例,任意1种症状得到缓解者10例,所有上述5种症状均未得到缓解者6例。以上5种症状中的任何一种症状得到缓解均视为有效,有效率为92%(66/72)。无任何并发症出现。结论:自体骨髓干细胞移植具有改善运动神经元病功能障碍的可行性,近期疗效确切。

AIM:To observe short- term effect of autograft of marrow stem cells(MSCs) on the treatment of motor neuron disease(MND),and study the role in improving the function.METHODS:Totally 72 patients who diagnosed as having MND in the Department of Neurology, the 463 Hospital of Chinese PLA,from February to October 2004 were treated with the autograft of MSCs.All patients were given some drugs that nurturea neurons in the perioperative period.The effective standards were whether the muscular tension was decreased,whether the slurred speech,dysphagia and the difficulty in raising the head were improved,whether the times of fasciculation were decreased and whether the myodynamia was increased.If any of the above symptoms became remissive, it would be considered to be effective.RESULTS:After the operation,the five symptoms in two patients were all relieved; any four symptoms in 6 patients,any three symptoms in 20 patients,any two symptoms in 28 patients and any one symptom in 10 patients were relieved; the five symptoms in 6 patients were not relieved.If any of the five symptoms became remissive it would be considered to be effective,then the effective rate was 92% (66/72),and none of them presented severe complications. CONCLUSION:MSCs autograft has the valid short- term clinical effect in improving the MND. #