摘要
为了提高产品质量的稳定性 ,实验研究了采用新菲尔对藻酸双酯钠片剂进行薄膜包衣的方法 ,并运用正交试验确定了薄膜包衣的最佳工艺条件为 :藻酸双酯钠片剂硬度为 3～ 4kg/mm2 ,包衣液浓度为 11% ,喷液流量为 0 .19kg/min ,片芯水分为 5 .0 %。采用新菲尔包制的薄膜衣片与藻酸双酯钠糖衣片相比较具有阻湿性能好 ,片剂增重小 ,工时短等优点。
The film coating process of Propylene glycol alginate sodium sulphate (PSS) prepared with Thin-film was studied, and the optimum conditions of PSS film-coated tablets were established using the orthogonal design method. The conditions are as follows. The hardness of PSS tablets is 3～4kg/mm2, the concentration of the coating material is 11%, the spray flow of the coating material is 0.19kg/min and the water content of PSS tablets is 5.0%. The results of quality test and accelerated stability test show that the film-coating can improve the moisture-resisting property and increase the quality stability of PSS tablets. In addition, the weight increment and the production time of PSS film-coated tablets are smaller and shorter than those of PSS sugar-coated tablets, respectively.
出处
《中国海洋大学学报（自然科学版）》
CAS
CSCD
北大核心
2005年第2期306-308,共3页
Periodical of Ocean University of China
关键词
藻酸双酯钠
新菲尔
薄膜衣片
糖衣片
正交试验
propylene glycol alginate sodium sulphate
thin-film
film-coated tablets
sugar-coated tablets
orthogonal design method
