肾移植患者sCD30的表达与急性排斥反应相关性的初步研究

The relationship between acute rejection and expression of sCD30 for the patients after kidney transplantation

目的研究sCD30与急性排斥反应的相关性。方法采用sCD30ELISA试剂盒(双抗体加心法)对58例首次肾移植患者术前1d、术后7d、28d进行了sCD30检测,31例健康者与术前1dsCD30做对照,并记录排斥反应的发生率。结果肾移植术前1dsCD30水平与急性排斥反应的相关性为X2=4.843,P<0.05,有显著性差异。肾移植术后第7天sCD30水平与急性排斥反应的相关性为X2=7.201,P<0.01,有高度显著性差异。肾移植术后第28天sCD30水平与急性排斥反应的相关性为X2=2.095,P<0.05,没有显著性差异。结论sCD30的高表达与急性排斥反应有关,sCD30在急性排斥反应中可能扮演了重要的角色。

Objective To study the relationship between the sCD30 and acute rejection.Methods We tested the sCD30 level in serum for 58 cases with kidney transplantation before and the 7th day and 28th day after operation by ELISA. 31 healthy individual for control group, and simultaneously recorded the incidence of rejection after kidney transplantation.Results The results showed that there is an obviously relation before kidney transplantation between the sCD30 level in serum and the incidence of acute rejection (chi=4.843,P=0.028, P<0.05). There is a significantly relation at the 7th day after kidney transplantation between the sCD30 level in serum and the incidence of acute rejection (chi=7.201,P=0.007, P<0.01). There is no obviously relation at 28 th day after kidney transplantation between the sCD30 level in serum and the incidence of acute rejection (chi=2.095,P=0.148, P>0.05).Conclusion The results suggested that the expressions of sCD30 are related to acute rejection. We speculated that the expressions of sCD30 could play an important role in acute rejection.