磁共振扩散成像评价梗阻性黄疸患者肝脏功能

Liver function in obstructive jaundice patients by diffusion-weighted MR imaging

目的 分析结石性梗阻性黄疸患者肝脏磁共振扩散成像的特点,探讨应用 ADC值分析肝脏功能的价值。方法 病例组为36例肝外结石性梗阻的患者,根据血清胆红素含量分为轻、中、重3组,对照组为10例健康志愿者。行DWI检查和肝脏功能实验室检查,计算对照组、不同病例组之间的 ADC值,分析各病例组 ADC值与实验室检查各指标之间的关系。结果 不同病例组组间的ADC值比较差异均有统计学意义(P<0.05)。轻度黄疸组肝脏 ADC值与对照组差异无统计学意义(P>0.05);中、重度黄疸组肝脏ADC值低于对照组差异有统计学意义。病例组肝脏 ADC值与实验室检查指标TBIL、DBIL、ALP、GGT 之间有相关性(P<0.01)。结论 应用DWI检查方法可以分析结石性梗阻性黄疸的肝脏功能。

Objective Diffusion-weighted imaging (DWI) of the liver was investigated to determine whether this method could be used to evaluate liver function in calculous obstructive jaundice patients by apparent diffusion coefficient (ADC) values. Methods Ten control subjects and thirty-six calculous obstructive jaundice patients were studied by using DWI and liver function laboratory examination. Thirty-six patients were divided into three-grade scale by the content of serum bilirubin in serum. ADC values and laboratory examination data were measured for ten control subjects and thirty-six calculous obstructive jaundice patients. The statistical correlation tests were used to determine the strength of the relationship between ADC values and laboratory examination data. Results There were statistically significant differences between obstructive jaundice patients in 3-grades (P<0.05).There were no significant differences between first-grade jaundice patients and control subjects (P>0.05); second-grade and third-grade jaundice patients had significantly lower than control subjects (P<(0.05)). There were statistically significant correlations between TBIL, DBIL, ALP, GGT, and ADCs (P<0.01). Conclusion Liver function in calculous obstructive jaundice patients may be analyzed by DWI.