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系统性硬皮病的治疗进展

The therapy adrances of systemic scleroderma (a review)
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摘要 系统性硬皮病是一种以皮肤及各系统胶原纤维硬化为特征的结缔组织疾病 ,本病目前尚无特殊疗法 ,获取良好的治疗效果 ,是临床医师期待解决的实际问题。为此 ,本文简要综述并分析当前国内外缓解该病的治疗方法 (如血管活性剂 ,结缔组织抑制剂 ,免疫抑制剂的应用 )并介绍新的治疗手段 ,如自体干细胞移植等。 This paper states the modern therapy of systemic sclero de rma contains:(1)connective tissue formation inhabitor,(2)vessel alivator,(3)immu nosuppressive agents,(4)improve Raynauds phenomenon,(5)to delay the harm of kedn ey,(6)to decrease the harm of lung,(7)to loose the harm of digestive tract,(8)tr ansplanation of autotegous stem cell,(9)intravenous immunoglobalin,(10)thalidomi d,(11)etretinate.atc.
作者 卜素玲
机构地区 天津市蓟县人民医院皮肤科
出处 《皮肤病与性病》 2005年第1期22-23,共2页 Dermatology and Venereology
关键词 系统性硬皮病 治疗进展 自体干细胞移植 血管活性剂 治疗手段 结缔组织疾病 临床医师 获取 实际问题 期待 Therapy advance systemic scleroderma review.
分类号 R593.25 [医药卫生—内科学] R259.932.5 [医药卫生—中西医结合]
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  • 2Seibold JR, Korn JH, Simms R, et al. Recombinant human relaxin in the treatment of scleroderma. a randomized, double - blind, placebo - controlled trial[ J ]. Ann Intern Med 2000,132: 8781 - 879.
  • 3Della Bellla S, Molteni M, Mascagni B,et al. Cytokine production in scleroderma patients:effects of therapy with either iloprost or nifedipine[J] .clin exp Rheumatol 1997,15:135 - 141.
  • 4Stratton R, Shiwen X, Martini G, et al. Iloprost suppresses connective tissue grouth factor production in fibroblasts and in the skin of scleroderma patients[J]. clin Invest 2001,108: 241 - 250.
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  • 7Dziadzio M, Denton CP, Smith R, et al. Losartan therapy for Raynaud's phenomenon and scleroderma: clinical and biochemical findings in a fifteenweek, randomized, parallel - group, controlled trial[ J]. Arthritis Rheum 1999,42:2646-2655.
  • 8Denton CP, Bunce TD, Darado MB, et al. Probucol improves symptoms and reduces lipoprotein oxidation susceptibility in patients with Raynaud' s phenomenon[ J]. Rheumatology ( Oxford ) 1999,38: 309 - 315.
  • 9Wigley FM,Sule SD.Novel therapy in the treatment of scleroderma[J] .Expert Opin Investi Drugs 2001,10:31 -48.
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皮肤病与性病
2005年 第1期

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