摘要
目的 观察鲑鱼降钙素对老年骨质疏松症的治疗效果。方法 将经定量CT(QCT)测定确 诊为骨质疏松且有临床症状的老年患者105例分成两组,鲑鱼降钙素组48例,予鲑鱼降钙素肌肉注射,每 天1次50IU,连用7d后,改为50IU隔天1次,连用14d后,改为50IU每周2次,连用4周为一个疗程,间 隔2个月后再重复,共1年,同时加服钙尔奇D(含元素钙600mg,维生素D125IU)每天1片;钙剂组57 例,单纯口服钙尔奇D每天1片,疗程1年,两组治疗前后均测定2～4腰椎(L2～4)骨密度(BMD),治疗前 后记录临床症状。结果 鲑鱼降钙素组较钙剂组骨痛症状缓解(89.6%和42.1%)效果明显(P<0.01), 鲑鱼降钙素组腰椎BMD治疗后(0.85±0.09)mg/cm3,较治疗前(0.81±0.05)mg/cm3有所升高(P< 0.05);钙剂组BMD无明显改变。结论 鲑鱼降钙素与钙剂联合应用对治疗老年骨质疏松症有缓解临床 症状及增加腰椎BMD的作用。
Objective To evaluate the effect of calcitonin on senile osteoporosis. Methods 105 senile osteoporosis patients diagnosed by quantitative CT (QCT) suffered low back pain. They were treated in two groups. 48 patients were in group one and treated by calcitonin and calcium carbonate vitamin D and the other 57 patients in group two treated by calcium only. The BMD of L 2～4 was examined before and after treatment. Severity of pain was also recorded before and after treatment. Results Bone pain relieving was much more obviously in calcitonin plus calcium treated group than in calcium treated group(P<0.01). BMD of L 2～4 in calcitonin plus calcium treated group showed significant change after treatment(P<0.05), while BMD of L 2～4 in calcium treated group showed little change after treatment. Conclusion Administration of calcintonin combined with calcium is effective in treating senile osteoporosis by improving BMD of lumbar vertebra and relieving bone pain.
出处
《中国骨肿瘤骨病》
2005年第1期27-28,共2页
Chinse Journal Of Bone Tumor And Bone Disease
