12例腹膜原发性浆液性乳头状癌临床诊治分析

Clinical analysis on diagnosis and treatment of 12 cases of primary peritoneal serous papillary carcinoma

目的 探讨腹膜原发性浆液性乳头状癌的临床特点、诊断标准、治疗方法和预后。方法 对1997年 1月～ 2 0 0 4年 12月在我院经病理确诊为腹膜原发性浆液性乳头状癌的 12例患者的临床资料进行回顾性分析。结果 所有患者均行肿瘤细胞减灭术 ,术后施以铂类为主的化疗方案。生存期大约 2 0个月的患者均接受 6次以上化疗 ,术前接受化疗的患者的平均生存期大于 2 8 3个月 ,较术前未行化疗者生存期长。结论 腹膜原发性浆液性乳头状癌是一种起病隐袭 ,发病率较低的恶性肿瘤 ,易被误诊。明确的诊断、术前化疗、手术的彻底性及术后足量的化疗可以延长患者的生存期。CA1 2

Objective To investigate the clinical features,diagnostic criterion,treatment and prognosis of primary peritoneal serous papillary carcinoma.Methods Twelve cases of histologically confirmed primary peritoneal serous papillary carcinoma treated in our hospital from 1997 to 2004 were retrospectively analyzed.Results In this series,all patients underwent cytoreductive surgery and platin-based chemotherapy.The patients who survived for more than 20 months received more than six cycles of chemotherapy.The patients received chemotherapy before surgery survived for more than 28.3 months,which was longer than those without chemotherapy before surgery.Conclusions Primary peritoneal serous papillary carcinoma is a rare tumor and difficult to be diagnosed preoperatively.The survival rate can be improved by the definite diagnosis,chemotherapy before surgery,optimal cytoreductive surgery and completed platin-based chemotherapy.CA 125 can be one of surveillant markers of this disease.