临床分离革兰阴性杆菌耐药性监测

Distribution and Resistance of Clinical Isolates of Gram-negative Bacilli: 1999 to 2003 Surveillance

目的 了解我院G-杆菌的分布及耐药情况。方法 药敏试验采用K-B纸片法,判断按NCCLS标准。 结果 1999-2003年临床分离的致病菌以G-杆菌为主,占74.9％,其中大肠埃希菌、铜绿假单胞菌、肺炎克雷伯 菌居前3位;对18种抗菌药物程度不同的耐药,产超广谱β-内酰胺酶(ESBLs)菌株的耐药性明显增高。结论 G-杆菌是医院感染的主要致病菌,监测G-杆菌耐药性对于临床合理选择抗菌药物十分重要。

OBJECTIVE To understand the distribution and resistance of Gram-negative bacilli in our hospital. METHODS K-B test was used for the antimicrobial susceptibilty test and the results were read based on National Committee for Clinical Laboratory Standards (NCCLS). RESULTS The clinical isolates were mainly Gram-negative pathogens (74.9%) from 1999 to 2003, of the first three were Escherichia coli, Pseudomonas aerugino-sa , and Klebsiella pneumoniae. They were resistant to some degrees to 18 kinds of antimicrobials. The resistance of ESBLs-producing strains increased prominently. CONCLUSIONS Gram-negative bacilli are main pathogens hospital infections it is important to investigate the information of Gram-negative bacilli and to monitor their drug resistance in order to reasonable use of antimicrobials.