P16在子宫内膜增生过长和子宫内膜癌中的表达和意义

The expression of p16 in proliferative endometrium and endometrial carcinoma

目的 探讨P16蛋白在子宫内膜癌发生和发展中的作用。方法 采用免疫组化法检测P16蛋白在 10例增生期子宫内膜、 10单纯型增生过长、 10例复杂型增生过长、 10例非典型增生过长和 5 0例子宫内膜癌中的表达。结果 在增生期子宫内膜、单纯型增生过长、复杂型增生过长、非典型增生过长和子宫内膜癌中P16的表达依次降低 ,子宫内膜癌中P16的表达与增生期子宫内膜相比 ,差异有显著性 (P <0 .0 5 )。P16在子宫内膜癌中表达在组织学分级G2 +G3与G1组 ;有淋巴结转移组与无淋巴结转移组比较 ,差异有显著性 (P <0 . 0 5 )。结论 P16表达与子宫内膜癌的发生发展相关 ,可作为子宫内膜癌的预后指标。

Objective To study the role of p16 in the genesis and development of endometrial carcinoma. Methods The expression of p16 was examined by immunohistochemistry in specimens of 50 endometria carcinoma,10 proliferative phase of endometrium, 10 simple hyperplasia,10 complex hyperplasia and 10 atypical hyperplasia. Results The positive-expression of p16 is associated with histologic grade and lymph node metastasis. The positive expression rate of p16 in proliferative phase of endometrium is significantly higher than that in endometrial carcinoma (P<0.05) . Conclusion The expression of p16 may play an important role in the genesis, development and prognosis of endometrial carcinoma.