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帕金森病发病机制的相关蛋白研究进展

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摘要 帕金森病(Parkinson disease,PD)是一种常见的神经变性疾病,由于中脑黑质多巴胺能神经元进行性变性坏死,造成多巴胺(dopamine,DA)生成障碍,残存的多巴胺神经元胞浆中出现淀粉样蛋白包涵体(Lewy小体).主要临床特征是静止性震颤、肌强直、运动减少和姿势平衡障碍等.大部分病人是散发的,部分和环境因素、遗传及年龄有关.
作者 夏鹰 江澄川
出处 《临床神经外科杂志》 CAS 2005年第1期46-48,共3页 Journal of Clinical Neurosurgery
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