摘要
目的:建立一个描述海马CA3-CA1突触长时程改变被诱导时,介导其形成过程的生化反应网络模型。方法:通过分析突触后钙依赖的信号转导通路中各主要信号蛋白酶的结构功能特性、相互作用关系,用数学函数描述介导突触长时程可塑性形成的生化网络动力学特征。结果:通过计算机仿真研究阐释了突触长时程修饰诱导形成过程中主要的钙信号转导机制。结论:为研究突触水平的学习记忆规律提供了一个仿真研究的平台。
Objective: The article aimed to construct a model for biochemical-react ion networks describing the process of CA3-CA1 synapses long term modification i nduction. Methods: By analyzing the functional and interactive relationship betw een the domnating signal proteins in the postsynaptic Ca2+-depended signal trans duction pathway, we use the mathematical functions to describe the dynamic chara cters of the biochemical-reaction networks, which mediating the process of synap tic long term modification forming. Results: Our computer simulation demonstrate s the foundation to the domnating calcium signal transduction mechanism during t he the process of hippocampal CA3- CA1 synaptic long term modification induction . Conclusion: It provides a simulation working platform for researching the rule of the learning and memory in synaptic level.
出处
《中国医学物理学杂志》
CSCD
2005年第2期456-459,共4页
Chinese Journal of Medical Physics
基金
国家自然科学基金(30125013
303300240)
教育部长江学者奖励计划资助项目
