摘要
用甲型流感病毒PR8株大剂量注射治疗老年小鼠S180腹水瘤,发现疗效不佳,小鼠生存率为零。为研究疗效不佳的原因,对荷瘤小鼠脾脏巨噬细胞吞噬功能、淋巴细胞总数及NK细胞活性进行了检测,结果如下。病毒治疗组老年小鼠巨噬细胞吞噬功能与未治疗组无明显差异(P>0.05);NK细胞杀伤率为14%,与对照组相同,而用病毒治疗的青年小鼠NK细胞杀伤活性明显升高,杀伤率为34.5%;淋巴细胞总数增长14.3%,与对照组无明显差别,但明显低于用病毒治疗的青年小鼠58.8%的增长率(P<0.0l).上述结果表明,病毒免疫治疗老年荷瘤小鼠时,小鼠的免疫监视功能未能被增强,这是造成疗效不佳的重要原因。
The viral
immunotherapy for ascitic tumor in young mice has some therapeutic effect。S180 ascitic
tumor in old mice were treated with a single large dose of influenza virus PR8strain, but the
theapeutic effect was poor andthe survival rate in the treated group wasO%。 The total
number of lymphocyte, the ac-tivity of macropage and nature killer cell)(NKC ) were detected in
order to study the factors of influencing the therapeutic effect. Theresults were as follows : The
activity of macrophage in old mice was not obviouslv differentbetween the treated and
untredted group (P>0. 05), the kill rate of NKC was l 4%; the ac-tivity of NKC of young mice in the
tredted group was obviusly enhanced, the kill rate was34.5%; the total number of lymphocyte in
old mice only increased l4.3%, but that inyoung mice increased 58.3%, there were significant
difference between old and young micein the treated group(P<0. 01 ). The activity of NKC, the
total number of lymphocyte andthe therapeutic effect in young mice were better obviously than
that in old mice, The resultssuggest that the function of immune surveillance can not be
enhanced in old mice after viralimmunotherapy and it is a main factor of influencing the
therapeutic effect。
出处
《延边医学院学报》
1994年第2期82-85,共4页
Journal of Medical Science Yanbian University
关键词
病毒
肿瘤细胞移植
治疗学
小鼠
virus
neoplasm transplantation
therapeutics
mice