摘要
用间接免疫荧光法检测了24例鼻咽癌患者与119例正常人血清中EB病毒4种特异性IgG抗体,结果表明,正常人血清中EB病毒衣壳抗原(WCA)的抗体效价为1:160以下,而鼻咽癌患者血清抗体效价为l:160~1:5120,抗体阳性率均为100%;正常人血清中EB病毒核抗原(EBNA)的抗体效价为1:80以下,而鼻咽患者血清抗体价为1:80~1:2560,阳性率均为100%;正常人血清中EB病毒早期抗原(EA)的抗体效价为l:10,阳性率只有13.3%,而鼻咽癌患者血清抗体效价为l:20~1:1280,阳性率为100%;正常人血清中EB病毒抗原(MA)的抗体效价为1:10~1:40,阳性率为71%,而鼻咽癌患者血清抗体效价为1:10~1:320,阳性率为100%.以上4种抗体中.VCA、EBNA和EA抗体的效价和分布在正常人与鼻咽癌患者之间有明显差异(P<姜勇男,男,31岁,讲师.延吉市局子街21号(133000)0.0l),EA抗体的阳性率也比正常人明显升高(P<0.0l),MA抗体的效价和阳性率与正常人相比无显著差异(P>0.05)。
Four
kinds of specific IgG antibodies to Epstein-Barr virus(EBV )were detected seraof 24 patients
affected by nasopharyngeal carcinoma (NPC) and 119 normal individual by indirect fluortescent
antibody test.The titer of antibody to virus capsid antigen(vcA)wa below l:l60 in normal
individuals and 1:160~1:5l20 in NPC patients,the positive rate in both of them was l00%. The
titer of antibody to Epestein-Barr nucleaf antigen(EBNA)was below l:80 in normal nidividuals
and l:8~1:2560 in NPC patients,the positive rate in both of them was l00%, too. In the normal
individuals and NPC patients,the titer ofantibody to membrane antigen(MA) was l:10~1:40 and
l:10~1:320, the positive ratewas 71% and l00%, the titer of antibody to early antigen(EA) was
l:10 and l :20~1:2560 and the positive rate was 13.3%and l00%, respectivelv. The results
indicate that the distribution and titer of antibodies to VCA, EBNA,and EA between the normal
individualsand NPC patients are statistically significant difference(P<0.01 ) and the positive
rate ofantibody to EA in NPC patientsis is higher markedly than that in the normal individuals
(P<0.01)。
出处
《延边医学院学报》
1994年第2期85-89,共5页
Journal of Medical Science Yanbian University
关键词
鼻咽肿瘤
E-B病毒
免疫球蛋白
抗体
nasopharyngeal neoplasms
Epstein-Barr virus
antibody, viral
Lserodiagnosis