甲氰咪胍与庆大霉素治疗幽门螺杆菌相关性消化性溃疡的治疗观察

Therapeutic observation of peptic ulcer relating to helicobacter pyloriwith cimetidine and gentamycin

将８３例胃镜诊断幽门螺杆菌阳性的消化性溃疡患者随机分组，观察溃疡愈合及幽门螺杆菌清除率．结果，甲氰咪胍与庆大霉素治疗组４２例中溃疡愈合３２例（７６％），甲氰咪胍对照组４１例中溃疡愈合３０例（７３％）；治疗组幽门螺杆菌清除２３例（５５％），对照组幽门螺杆菌清除５例（１３％）；幽门螺杆菌清除者溃疡愈合３０例（５４％）．１年后复查，幽门螺杆菌清除者溃疡复发３例（１２％）；幽门螺杆菌未清除者复发１１例（３６％）．口服庆大霉素对清除幽门螺杆菌有一定的疗效，而幽门螺杆菌清除者溃疡复发率低。

the correlation between the helicobacter pylori (HP) and the peptic ulcer, chronic gas-tritis had been noticed since recent years.83 cases of the peptic ulcer that the HP was pos-itive and were diagnosed by gastroscope were randomly divided into the therapeutic and con- trol group .The cimetidine and gentamycin were given orally in therapeutic group and thecimetidine was only given In control group.The therapeutic course of two groups all was 5weeks。The uicer healing and Clearance rate of the HP were observed after treatment, Theresults showed that there were 32,cases(76%)of ulcer healing in the therapeutic group and30 cases (73%)in the control group; 23 cases(54.7%)in the therapeutic group clearedaway the HP and 5 cases(13%)in control group; the ulcer healing that cleared away theHP was 25 cases( 89%);and that did not clear away the HP was 30 cases(54%).On reex-amination one year later, 3(12%)of peptic ulcer that cleared away HP and 11 cases (36.6%) that did not clear away HP recurred. The results indicate that the gentamycin given orally has some therapeutic effect for clearing away the HP and the recurrent tate of peptic ulcer that cleared away HP is low.