酒石酸锗复合物的抗炎作用及作用机理

Antiinfammatory action Of germanium tartate complex

灌胃酒石酸锗复合物２０ｍｇ·ｋｇ－１，明显地抑制二甲苯或巴豆油所致小鼠耳壳肿胀，抑制角叉菜所致大鼠足肿胀，抑制小鼠棉球肉芽肿增生及佛氏完全佐剂所致大鼠关节炎．这表明，酒石酸锗夏合物具有抑制急、慢性及免疫性炎症的作用，还降低小鼠毛细血管通透性，增强小鼠单核巨噬细胞系统的吞噬功能，抑制大鼠热烫足肿胀，减少大鼠炎症部位的ＰＣＥ２含量．提示，酒石酸锗复合物的抗炎作用与降低毛细血管通透性，增强单核巨噬细胞的吞噬功能和抑制炎症部位的激肽类、ＰＧＥ２的合成、释放有关．

The antiinflammatory action of germanium tartrate complex(Ge ) was investigated inrats and micc. The results showed that germanium ( 20mg/kg ) inhibited several inflammato-ry processes such as edema induced by xylene and croton oil in the ear of mice, prolifera-tion of granuloma induced by cotton-pellets in mice, edema induced by carrageenin in thehind paw and arthritis induced by adjuvant in rats. These results suggest that germaniumhas an inhibitory action for acute,chronic and immune inflammation. Also, germanium in-hibited capillary permeability,increased phagocytic function of the mononuclear phagocytesvstem in mice. In addition,germanium inhibitcd scald oedema,and decreased the contentsof prostaglandin E2in its inflammatory site. Based on thesc results, we suggest that the an-tiinflammatory action of germanium may be involved with increasing phagocytic function ofmononuclear phagocytc system, inhibiting capillary permcability and bradykinin andprostaglandin E2synthesis or release.