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分子进化研究中的几个统计量及其应用 被引量：1

Some Statistical Parameters in Molecular Evolution and Their Application
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摘要 为在分子水平上快速精确地研究生物的进化关系,提出了分子进化研究中的几个常用统计量及其计算方法.根据这些统计量探测正选择作用,并确定特定基因的进化速度或年龄.这些统计量包括核苷酸同义替换数ds(Ks)、非同义替换数dn(Ka)、Ka／Ks、DNA多态性和遗传距离等.通过植物抗性基因的一个实例揭示了这些统计量在阐明进化机制过程中的重要性. The precise evolution relationship and phylogenetic tree can be obtained with the aid of analyses and calculations of certain gene data. Some statistical parameters of molecular evolution were introduced and their application was explained, including Ka (nonsynonymous nucleotide substitutions), Ks (synonymous nu-cleotide substitutions) and Ka/Ks. The other important parameters, for example DNA polymorphism and genetic distance, were also discussed. Based on these evolution statistical parameters, the positive selection and gene evolution speed could be determined. An example was used to reveal the evolution mechanism of plant resistant genes with analyses of three parameters.
作者 陈建群 王友红 蒋科 张晖
机构地区 南京大学生物科学与技术系
出处 《北京工业大学学报》 CAS CSCD 北大核心 2005年第2期194-198,共5页 Journal of Beijing University of Technology
基金 国家自然科学基金资助项目(30470122).
关键词 核苷酸非同义替换数dn(Ka) 核苷酸同义替换数ds(Ks) dn(Ka)/ds(Ks) DNA多态性 遗传距离 nonsynonymous nucleotide substitutions (dn, Ka) synonymous nucleotide substitutions (ds, Ks) dn(Ka)/ds(Ks) DNA polymorphism genetic distance
分类号 Q349 [生物学—遗传学]
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参考文献12

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同被引文献30

  • 1Fry WE,Goodwin SB.Resurgence of the Irish potato famine fungus.BioScience,1997,47(6):363-371.
  • 2Kamoun S.Nonhost resistance to Phytophthora:novel prospects for a classical problem.Curr Opin Plant Biol,2001,4(4):295–300.
  • 3Daayf F,Platt HW.Changes in metalaxyl resistance among glucose phosphate isomerase genotypes of Phytophthora infestans in Canada during 1997 and 1998.Am J Potato Res,2000,77(5):311–318.
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  • 5van der Vossen EA,Sikkema A,Hekkert BL,Gros J,Stevens P,Muskens M,Wouters D,Pereira A,Stiekema W,Allefs S.An ancient R gene from the wild potato species Solanum bulbocastanum confers broad-spectrum resistance to Phytophthora infestans in cultivated potato and tomato.Plant J,2003,36(6):867–882.
  • 6Song JQ,Bradeen JM,Naess SK,Raasch JA,Wielgus SM,Haberlach GT,Liu J,Kuang HH,Austin-Phillips S,Buell CR,Helgeson JP,Jiang JM.Gene RB cloned from Solanum bulbocastanum confers broad spectrum resistance to potato late blight.Proc Natl Acad Sci USA,2003,100(16):9128–9133.
  • 7van der Vossen EAG,Gros J,Sikkema A,Muskens M,Wouters D,Wolters P,Pereira A,Allefs S.The Rpi-blb2 gene from Solanum bulbocastanum is an Mi-1 gene homolog conferring broad-spectrum late blight resistance in potato.Plant J,2005,44(2):208–222.
  • 8Park TH,Gros J,Sikkema A,Vleeshouwers VGAA,Muskens M,Allefs S,Jacobsen E,Visser RGF,van der Vossen EAG.The late blight resistance locus Rpi-blb3 from Solanum bulbocastanum belongs to a major late blight R gene cluster on chromosome 4 of potato.Mol Plant-Microbe Interact,2005,18(7):722–729.
  • 9Park TH,Foster S,Brigneti G,Jones JDG.Two distinct potato late blight resistance genes from Solanum berthaultii are located on chromosome 10.Euphytica,2009,165(2):269–278.
  • 10Rauscher GM,Smart CD,Simko I,Bonierbale M,Mayton H,Greenland A,Fry WE.Characterization and mapping of RPi-ber,a novel potato late blight resistance gene from Solanum berthaultii.Theor Appl Genet,2006,112(4):674–687.

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北京工业大学学报
2005年 第2期

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