摘要
用高效液相色谱法测定了单纯双氯灭痛、双氯灭痛β-环糊精包合物(共沉淀法、冷冻干燥法)三种样品在家兔体内的血浓度,在IBM计算机上求算药动学参数。相对生物利用度分别为847.518%(共沉淀法),878.523%(冷冻干燥法).双氯灭痛在体内的分布呈一室模型。
The plasma concentrations of the intact diclofenac sodium (coprecipitation method),diclofenac sodium β-cyclodextrin inclusion compound(coprecipitation method and freeze-dried method) in rabbits were determined by high performance liquid chromatography, and the pharmacokinetcs parameters were calculated using IBM computer.The relativebioavailabilities were 847. 51 8%(coprecipitation method),878.523%(freeze-dried method),respectively. Distribution of diclofenac sodium in the plasma of rabbit showed open one compartment linear model.
出处
《延边医学院学报》
CAS
1994年第4期273-276,共4页
Journal of Medical Science Yanbian University