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磁共振波谱分析与癫痫临床 被引量：3

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摘要 磁共振波谱(MRS)是一新兴无创性检查手段,已应用于癫痫的诊断及疗效评价。与MRI及PET相比,MRS 可更敏感的发现病灶。目前,1H MRS应用最广泛,颞叶癫痫患者病灶内NAA浓度、NAA／(Cho+Cr)比值明显降低, 部分单侧病灶患者会出现双侧NAA改变,是继发还是原发仍有争议;全面发作性癫痫患者额叶或丘脑也出现NAA／ (Cho+Cr)比值降低。癫痫发作后,还可观察到病灶内Glu含量升高、GABA含量降低,有效的抗癫痫治疗后,各指标 恢复到正常水平。31P MRS中Pcr／Pi比值降低、PME减少和pH值升高也见于癫痫发作后。总之,MRS可在生化代谢 水平来反映和评价疾病,已显示出极大地临床应用价值。
作者 王胜军 迟兆富
机构地区 山东大学齐鲁医院神经内科
出处 《国外医学（神经病学．神经外科学分册）》 2005年第1期52-55,共4页 Foreign Medical Sciences（Section On Neurology & Neurosurgery）
关键词 MRS 癫痫发作 患者 磁共振波谱分析 病灶内 比值 升高 NAA GABA 水平
分类号 R742.1 [医药卫生—神经病学与精神病学] R573 [医药卫生—消化系统]
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同被引文献43

  • 1居胜红,陈峰,滕皋军,杨天明,郑凯尔,季倩,张琳琴,金琴娣,孟爱芳,谭启富.MR单体素波谱和化学位移成像在颞叶癫痫中的研究[J].中华放射学杂志,2004,38(11):1180-1185. 被引量：11
  • 2郑加平,迟兆富.磁共振质子波谱与癫痫[J].脑与神经疾病杂志,2005,13(2):151-152. 被引量：5
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  • 10Savic I, Osterman Y, Helms G. MRS shows syndrome differentiated metabolite changes in human-generalized epilepsies. Neuroimage, 2004, 21: 163-172.

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国外医学（神经病学．神经外科学分册）
2005年 第1期

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