克山病与乙型肝炎病毒感染的病例对照研究

A case-control study on Keshan disease and hepatitis Bvirus infection in Keshan disease endemic area

目的 探讨克山病与乙型肝炎病毒 (HBV)感染的关系。方法 采用病例对照研究方法 ,以确诊的 12 7例克山病人为病例组 ,平衡年龄、性别和民族等影响因素 ,随机抽 12 2例病区健康人作为内对照组 ,非病区健康人 47例为外对照组 ;用酶联免疫 (ELISA)法筛检 3组人群中HBV感染者。数据资料管理和 χ2 检验在SPSS10 .0软件包上进行。结果 HBV感染率在病区与非病区人群间有显著性差异 (P <0 .0 1,OR =3 .94) ,而病区健康人群与克山病人群间无显著性差异 (P >0 .0 5 )。提示克山病与HBV感染有关联 ,且呈剂量 -反应关系 (r =0 .93 5 ,P <0 .0 1)。结论 在克山病区 ,HBV感染可能是人易患克山病的重要危险因素 ,应当重视人群中HBV感染的监测和预防 。

Objective To probe the relationship between Keshan disease and hepatitis B virus(HBV) infection.Methods A case-control study was carried out,127 cases of Keshan disease and 122 inner-controls collected from 6 villages of Keshan disease endemic area,47 outer-controls from 2 villages of non-Keshan disease endemic area were interviewed.The relevant factors in a total of a case group and two control groups matched by age、sex and nationality were detected for HBsAg、anti-HBs、HBcAg、anti-HBc、anti-HBe by enzyme linked immunoassays(ELISA).The data were analyzed with SPSS10.0 software.Results The positive rate of HBV in the case group and the outer-control group was significant (P<0.01) and in the case group and the inner-control group was no significant(P>0.05).Exposure to HBV infection was a risky factor of Keshan disease and there existed relationship of dosage-reaction in Keshan disease endemic area (r=0.935,P<0.01).Conclusion Exposure to HBV infection may be a risky factor for Keshan disease.More epidemiological studies on the field would be conducted.