2型糖尿病家系危险因素Logistic回归分析

Logistic regresssion of risk factors in type 2 diabetes mellitus pedigrees

目的 研究家系人群中 2型糖尿病 (T2 DM)的危险因素 ,为制定干预措施提供依据。方法 利用葡萄糖耐量试验 (OGTT)、PCR -RFLP和免疫法排除其他类型后确定了 115个 2型糖尿病家系 ,通过问卷调查和实验室检查收集危险因素的情况 ,并采用Logistic回归分析方法对新老 2型糖尿病患者和糖耐量低减 (IGT)患者危险因素进行分析。结果 糖尿病患者的多因素分析显示 ,T2 DM患者的年龄 (OR =1 0 4 3,95 %CI1 0 2 4～ 1 0 6 2 )、高血脂史 (OR=4 4 71,95 %CI2 14 9～ 9 30 3)、高血压史 (OR =2 0 75 ,95 %CI1 0 0 1～ 4 30 1)和腰臀比超标 (OR =1 80 9,95 %CI1 0 0～ 4 30 1)是独立的危险因素 ,而新诊断患者仅高血压史 (OR =6 0 6 8,95 %CI1 6 97～ 2 1 6 89)是独立的危险因素 ,IGT患者的年龄 (OR =1 398,95 %CI～ 1 138～ 1 717)是危险因素。结论 在本研究人群中 ,高血压、年龄、中心性肥胖可能是

Objective To explore the risk factors of type 2 diabetes mellitus in T 2DM pedigrees.Methods One hundred and fifteen pedigrees of type 2 DM were diagnosed with OGTT,PCR-RFLP,GAD and ICA512.Risk factors were analyzed by Logistic regression.Results Hypertension( OR =2 075,95% CI 1 001-4 301),hyperlipidemia( OR =4 471,95% CI 2 149-9 303),high waist hip ratio( OR =1 809,95% CI 1 001-4 301) and age ( OR =1 043,95% CI 1 024-1 062), were significant in multiple-regression of risk factors in T 2DM.In new diagnosed T 2DM,hypertension( OR =6 068,95% CI 1 697-21 689) was significant.Age ( OR =1 398,95% CI 1 138-1 717) was significant in IGT.Conclusion Hypertension,age and visceral obesity were risk factors of T 2DM probably.