急性白血病危险因素的多元Logistic回归分析

Logistic regression analysis on risk factors of acute leukemia

目的 探讨急性白血病的可疑危险因素。方法 对 12 2例 15岁以上的急性白血病患者进行 1∶1配对的病例 -对照研究 ,调查患者的既往病史、用药史、居住环境、职业暴露史、家居装潢史、吸烟史、染发史、家族肿瘤史等 ,并应用条件Logistic回归模型进行分析。 结果 4 7项指标中有 10项在单因素分析中有统计学意义 ,6项在多因素分析中有统计学意义 ,分别是解热镇痛类药物服用史、氯霉素服用史、X线接触史、化学有机溶剂接触史、家居装潢至搬入间隔和染发频率。

Objective To explore suspicious risk factors of acute leukemia.Methods 1∶1 case control study was applied to investigate acute leukemia patients aged 15 and elder with conditional Logistic model.Results In the single factor analysis,10 of 47 indexes were obviously significant.While 6 of 47 indexes were obviously significant in the multi-factor stepwise analysis,which including febrifuge and anodyne administration,chloromycetin administration,exposure to X-ray,chemical organic solvents,interval of moving in aafter house decoration,frequency of hair dye use.Conclusion The existence of these factors might increase the risk of acute leukemia.