农牧区蒙古族居民高血压家庭聚集性分析

Familial aggregation analysis on hypertension among Mongolian people in agricult ure and animal husbandry area

目的 探讨蒙古族高血压的家庭聚集性及遗传和环境的相对作用。方法 对现场内的研究对象进行血压测量及家系调查 ,描绘家系谱图。用二项分布拟合优度 χ2 检验方法及相关分析法分析高血压的家庭聚集性及家庭内各成员间的血压相关性。结果 蒙古族高血压的分布不呈二项分布 ,存在着家庭聚集现象 ;家庭各成员间血压都具有显著性相关 ,其中同胞间的相关系数最高 ,同胞间收缩压与舒张压的相关系数分别为 0 38和 0 32。按妻子年龄分层后 ,分析夫妻间的血压相关性 ,只有妻子年龄≥ 5 0岁的夫妻血压有显著性差异。结论 蒙古族高血压存在着家庭聚集性 。

Objective To explore the familial aggregation of hyperten sion and relative action of genetic and environmental factors on hypertension in Mongolian people.Methods The blood pressures of the subjects were measured and the family trees were investigated in the field,and then the diagram of the family trees were drawn.The familial aggregation of hypertension and correlation coefficients for blood pressure among the members of family were analyzed by means of the χ2 test for goodness-of-fit to binomial distribution and corre lation analysis.Results The distribution of hypertension was not fit to b inomial distribution,which implied hypertension was with familial aggregation in Mongolian people;the correlation coefficients for blood pressures were signific ant among all members of family;correlation coefficient between the siblings wer e the highest in the family members,with 0.38 and 0.32 for DBP and SBP,respecti vely.After spouses were stratified by the age of wife,significant correlation co efficient for blood pressure was found only between spouses with wife elder than 50 years old.Conclusion Hypertension was with familial aggregation amo ng Mongolian people,which was determined by genetic and environmental factors.