儿童高血压危险因素研究

Study on risk factors of children's hypertension in north of china

目的 了解儿童血压水平及高血压的发生状况 ,初步探索儿童原发性高血压的易患因素。方法 用整群抽样的方法对北票市城乡 7～ 14岁儿童 5 76 2名进行血压测量 ,将发现的所有高血压者作为病例组 ,用随机抽样的方法在所有正常儿童中选择对照组 ,进行 1∶1病例对照配对。所有儿童均填写统一制定的调查表 ,并做血常规检查 ,包括 18项血液学指标。采用SPSS 10 0软件进行有关的统计分析。结果 单因素分析显示 :体质指数 (BMI)升高是儿童高血压的重要危险因素。将收缩压 (SBP)和舒张压 (DBP)分别进行分析 ,发现BMI、月经初潮、白细胞 (WBC)、淋巴细胞计数 (LYM)、单核细胞百分比 (MON % )、单核细胞计数 (MON)与是收缩期高血压的危险因素 ;BMI也是舒张期高血压的危险因素。多因素Logistic回归分析显示 :BMI是儿童高血压发病的危险因素。收缩期高血压发病的危险因素有BMI、WBC、MON % ;舒张期高血压发病的危险因素有BMI。结论 肥胖是儿童高血压的重要危险因素 ,与收缩期及舒张期高血压均有关系。WBC和MON %的升高是收缩期高血压的危险因素。

Objective To know the status of children's blood pressure and the risk factors of children's hypertension.Methods 5?762 children of 7～14 years were sampled b y means of whole population random sampling.Blood pressure was measured,the rela ted risk factors were investigated with the uniform questionnaire and hematology indexes were detected.Case control study including 163 cases and control group with a ratio of 1 to 1.Spss 10.0 of statistical software was used for date analy sis.Results 1.Single factor analysis showed:BMI was risk fact or of hypertension(OR=3.16,95%CI:1.95-5.11).Analysised SBP and DBP respecti vely,body mass index(BMI),menarche,white blood cell(WBC),1ymphocyt e(LYM),monocyte(MON)and monocyte percent(MON%)were risk factors of systolic hype rtension (OR value were 4.05(95%CI:2.35～6.97),3.95(95%CI:1.69～9.23) ,1.98(95%CI:1.15～3.41),1.92(95%CI:1.10～3.33),3.59(95%CI:1.69～7 .61),2.33(95%CI:1.32～4.09)respectively,BMI was also risk factors of diasto lic hypertension,OR=2.43(95%CI:1.52～3.89).2.Multivariate analysis indicate d that only BMI could enter the model of hypertension(OR 3.16 95%CI:1.95～5. 11);BIM,WBC,MON% could enter the model of the systolic pressure,OR value was 4.5 6(95%CI:2.56～8.12),2.03(95%CI:1.13～3.65)5.11(95%CI:1.52～3.89)resp ectively;Only BMI could enter the model of the diastolic pressure(OR 2.43 95%C I:1.52～3.89).Conclusion Obese was an important risk factor of child hy pertension and it acted on both SBP and DBP.The increasing of WBC and MON% were risk factors of SBP.