精神药物对856例患者白细胞的影响

The Influence on White Blood Cell by Psychotropic Drug in 856 Patients

对856例住院患者在用精神药物治疗中白细胞变化进行了分析,发现白细胞增多11.1%,减少3.6%,粒细胞缺乏0.2%.白细胞减少病例中,以氯氮平、氯丙嗪及舒必利引起者严重,尤以氯氮平为甚,一旦发生,进展快,若出现粒细胞缺乏,不及时抢救,可在短期内死亡.指出服精神药物的患者应定期检查白细胞计数及分类.

Authors analysed the change of WBC during psychotropic therapy in 856 patients. we found that 11. 1% of all patients appeared leukocytosis, 3. 6% was leukocytopenia, 0.2% was agranulocy-tosis. In all leukocytopenia, the influence by clozepine, clorpromazine and sulpiride were serious, especially by clozepine. The leukocytopenia patients would have died in short time if it was not rescued promptly when agranulocytosis had appeared. It is necessary to examine WBC count and classification regularly in patients by psychotropics therapy.