氨氯地平与尼群地平治疗高血压病的平行对照研究

The Comparative Study on Treatment of Hypertension with Amlodipine and Nitrendipine

应用氨氯地平(Amlodipine)与尼群地平(Nitrendipine)对120例轻、中度原发性高血压患者采用随机单盲平行组间对照法进行临床研究。结果显示:①氨氯地平总有效率90％,尼群地平总有效率80％,差异无显著性意义(P>0.05);②氨氯地平的降压幅度大于尼群地平,但仅舒张压降低幅度的比较有统计学意义(P<0.01);③对心率、血象、血糖、血脂、血尿酸、血清电解质和肝、肾功能均未发现不良影响;④氨地平半衰期较长,降压作用较持久,每日只需服用1次(5或10mg),较尼群地平更为方便。

Amlodipine which has the similar chemical structure to nitrendipine is the third generation of calcium antagonist. It is used in some countries for treating hypertension and myocardial ischemia with a good effect. 120 patients with primary hypertension were selected, stage I and II are 60 cases respectively, male : femele=l:1, the range of ages is 27-65. The patients were randomized into 2 groups (Group A:amlodipine, n=80;Group B:nitrendipine, n=40). Group A takes amlodlpine 5-10mg once a day. Course of treatment is 4 weeks.Total efficiency of Group A is 90%, Group B 80% (P>0. 05). The decrease of BP in Group A is 27. 65±10. 82/15. 22±6.13mmHg; Group B 23. 53±12. 15/11. 93±5. 60mmHg. The decrease of dias-tolic pressure between 2 groups is prominent, P<0.01. There are no side effects of both drugs on heart rate, blood tests, blood glucose, lipid, uric acid, electrolytes, hepatic and nephritic function, and no postural hypotension. T1/2 of Amlodipine is 35-50 Hrs. It is more convenient than Nitrendipine for taking one time per day.