462例精神分裂症治疗用药分析

Analysis of Drug Therapy in 462 Schizophrenia Patients

回顾性分析462例精神分裂症的用药.143例单用药7种,频度高者依次为氯氮平,氯丙嗪、氟哌啶醇、奋乃静及舒必利.合并用药中二药合用182例,用药12种.三药合用104例用药14种,.二药及三药合用频度高的药物皆为氟哌啶醇、氯氮平、氯丙嗪、舒必利、及奋乃静.单用药与各种合并用药的疗效比较,差异皆不显著(P>0.05),总有效率皆达95.8%以上.合并用药过多,种类过繁但不增加疗效,应加以改进.

Review analysis of drug usage in 462 Schizo phrenia patients was made. Seven kinds of single drug were used in 143 patients. The usage frequences from high to low were: Clozapine (L), Chlor-promazine (C), Haloperadol (H), Perphenazine (P), and Sulpiride (U). In different kinds of drug combination , the frequency of two drugs combination (182 patients) was the most. 12 kinds of drug were administered for two drugs combination. There were 14 kinds of drug to be used for three drugs combination in 104 patients. In two and three drugs combinations, the high frequency drugs were: H, L, L, U, and P. The therapeutic efficiency differences of single drug and drug combinations were all non-significant (P> 0. 05) . Their total therapeutic efficiency rates were all over 95. 8%. It was inappropiate by using too much combinations and too much kinds of regimens. Improvement should be made.